I have been using Tiny Bubbles for well over 2 years in my normal, bordering on hard water. I have never needed to strip, I use 2 scoops in my top loader, run a full cycle on warm, then an extra rinse. Easy. We have all GroVia or prefolds, and a few WAHM fitteds.
I have never stripped, and only bleach when yeast is present or a terrible stomach bug hits. If I felt I needed it, or had harder water, I would use Mighty Bubbles laundry treatment without hesitation, but I haven't needed it.