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Old 09-04-2012, 08:16 AM   #1
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Little e antibody

I'm not sure if this is the best place to post this or not. If it needs to be moved please do so.


I just received a phone call from my doctor telling me about a blood draw I had at my appointment last week. At one of my first appointments a little e antibody. Well when they redid the blood draw my titer levels went from 2 to 16. I have to go and see the maternal featal specialist about it tomorrow. I was wondering if anyone had any experience with this. I would like an idea of what to expect.
I tried doing a search for it but couldn't find much of anything. If anyone has any idea what this is I would appreciate a little insight before my appointment tomoorw.

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Old 09-04-2012, 08:46 AM   #2
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Re: Little e antibody

Our blood cells have many, many proteins on them and we all have slightly different ones. Some are more common than others. The most common example that we all know about is being RH negative or positive. When a woman is RH negative and is lacking that particular protein AND is pregnant by a man whop carries it then the baby possibly also having that protein on its blood can cause Mama to react to the protein. That reaction can cause major problems in later pregnancies.

My best educated guess is that "little e" is another protein, which you do not have and your husband does. You had one baby who had it as well...your body reacted to it, possibly causing your stillborn little ones. Apparently your body is reacting again, meaning this baby has it. Now that they are aware of it you and your little one have a fighting chance to treat it. Hopefully the MFM has a better explanation and some good ideas for how to treat it.

Praying for you!
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Old 09-04-2012, 11:20 AM   #3
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I had anti-e antibody with this pregnancy. It is an antibody to a protein that is present in your husband's blood but not yours. My titers never got high enough to cause them any concern, but from the research I did, apparently it can cause anemia in the baby. If your titers are high enough, they will most likely do monthly ultrasounds to check for anemia, and if baby becomes anemic they can do fetal blood transfusions and worst case scenario is early delivery. From what I read, this is not a fatal condition for the baby and can be treated. Best of luck, mama. It's very scary. I'll be praying for an uncomplicated pregnancy for you.
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Old 09-04-2012, 11:28 AM   #4
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Re: Little e antibody

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Originally Posted by weesej View Post
Our blood cells have many, many proteins on them and we all have slightly different ones. Some are more common than others. The most common example that we all know about is being RH negative or positive. When a woman is RH negative and is lacking that particular protein AND is pregnant by a man whop carries it then the baby possibly also having that protein on its blood can cause Mama to react to the protein. That reaction can cause major problems in later pregnancies.

My best educated guess is that "little e" is another protein, which you do not have and your husband does. You had one baby who had it as well...your body reacted to it, possibly causing your stillborn little ones. Apparently your body is reacting again, meaning this baby has it. Now that they are aware of it you and your little one have a fighting chance to treat it. Hopefully the MFM has a better explanation and some good ideas for how to treat it.

Praying for you!
Thank you.
My previous still births are actually from a blood clotting disorder. I wonder though since with DD i was being treated the same as with DS2 if this helped contribute to her loss. Nothing was ever said about it until this pregnancy which makes me wonder if it was with her that it first appeared.

I hope the MFM can help. My doctor seemed concerned and spoke with them himself to get me seen ASAP.
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Old 09-04-2012, 11:30 AM   #5
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Re: Little e antibody

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Originally Posted by erlyjo View Post
I had anti-e antibody with this pregnancy. It is an antibody to a protein that is present in your husband's blood but not yours. My titers never got high enough to cause them any concern, but from the research I did, apparently it can cause anemia in the baby. If your titers are high enough, they will most likely do monthly ultrasounds to check for anemia, and if baby becomes anemic they can do fetal blood transfusions and worst case scenario is early delivery. From what I read, this is not a fatal condition for the baby and can be treated. Best of luck, mama. It's very scary. I'll be praying for an uncomplicated pregnancy for you.
Thank you for telling me what to expect. And since I already receive monthly US it won't be any more appointments for me or work for the Doctors to keep an eye on her. I hope everything turns out fine and that i dont have to deliver early.
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Old 09-06-2012, 06:52 AM   #6
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Re: Little e antibody

I have anti E. They found it when I was pregnant with #2. So far it hasn't caused me any problems, or I guess I should say, it hasn't caused the baby any problems. It doesn't hurt the mom at all.

Check your medical record to see when it first showed up. If you were getting regular prenatal care (ie., not from a homebirth midwife) then your titers were checked at your initial visit,at 28 weeks, and again at delivery. That's the standard of care, so my guess is,if they didn't tell you that you tested +, then you probably didn't, and the antibody likely didn't have anything to do with your losses.

Isoimmunization is nothing to mess around with. Thankfully it can be treated, so something that used to be a death sentence is really just a hassle. This is another triumph for modern medical care.

Typically, you will have your antibodies drawn every month of pregnancy, until the third trimester and then it will be every 2 weeks. Some MFM's will schedule an u/s to check the MCA pressure (middle cerebral artery) which can be a sign of anemia. What happens is, your blood starts killing off the RBC in the baby's blood. So the baby becomes anemic. In order to compensate for the loss of blood volume, the baby starts increasing blood volume, and therefore, blood pressure. An increase in the pressure in the MCA is a sign that the baby is anemic and trying to stay alive, basically. That normally doesn't happen until your titers start going way up, but some MFM's are more cautious and will do one anyway. I believe it has to be done by someone specially trained, so while I get u/s at every visit (checking for growth, I had a previous pre-term delivery due to IUGR and placental insufficiency) they can't check the MCA in the office.

Anti E is a tricky little bugger. Sometimes it never causes a problem, and sometimes it can be a real PITA. More often it doesn't cause a problem, but when it does it can be pretty serious. at dh's hospital (he's in newborn intensive care) they have had some women, like me, that have never had a problem with it, and some that do. Supposedly, past pregnancies predict future pregnancies, so while they keep a close eye on me, everyone is optimistic that it will not be an issue.

If you have any questions you can shoot me a PM. Good luck with your pregnancy, and I'm sorry about your losses.
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